It’s not so long ago that Bilbao was a grim and unappealing place, scarred by heavy industry, but the Basque Country’s biggest city has reinvented itself as a cultural hub since the opening of the shimmering Guggenheim Museum in 1997.

The Galician city of Ferrol, birthplace of General Franco, doesn’t feature on too many tourist itineraries, though maritime enthusiasts may enjoy a visit to the 18th-century shipyards. Most cruise visitors will use Ferrol as a base to explore Galicia’s wild coast, the nearby city of La Coruña or the famous pilgrimage site of Santiago de Compostela.

Spread across steep hillsides that overlook the Rio Tejo, Lisbon’s colourful cityscape includes Gothic cathedrals, majestic monasteries and quaint museums. But for many the best times will be had wandering the narrow lanes of Lisbon’s lovely backstreets, with their great local food, wine and music.

Seville is a wonderful destination, a sophisticated and sun-kissed city on the banks of the Guadalquivir river. It’s a treat for all the senses, from the smell of orange blossom to the heart-tugging sounds of flamenco, and the highlight of the calendar is undoubtedly Semana Santa, when a spectacular Easter parade fills the streets.

Sovereignty of ‘The Rock’ has been a thorny issue ever since Gibraltar was ceded to Britain in 1713, though on the ground it’s clear where most locals’ sympathies lie. Gibraltar is often described as ‘more British than Britain’, a curious enclave of red postboxes, double decker buses and chip shops.

Málaga boasts plenty of chic restaurants and bars where you can ease into the rhythms of life in southern Spain, before exploring sights including the intriguing, unfinished Gothic cathedral, and a museum devoted to the city's most famous son, Pablo Picasso.

Cartagena was founded by the Carthaginians around 227 BC, who named it after their home city in North Africa. These days the city is best known for its well-preserved Roman theatre, which was remarkably only discovered in 1987, in spite of its location in the centre of town.

Spain’s third city is a dazzling destination that combines historic architecture, cutting edge design and an inviting stretch of beach. Don’t miss the futuristic City of Arts and Sciences, designed by local architect Santiago Calatrava, or the old riverbed, now a delightful park.