Genoa has a legendary seafaring heritage, and was once a powerful maritime republic. However, the city’s most famous son, Christopher Columbus, was spurned by the Genoese elite when he came looking for funds for his expedition, and his discoveries for the Spanish Crown ironically played no small part in Genoa’s downfall.

The faded port town of Livorno serves as a gateway to Tuscany’s star attractions. Wonderful Florence, the cradle of the Renaissance, is resplendent with beautiful architecture and unrivalled artistic treasures, while nearby Pisa is of course famous for its precarious Leaning Tower.

Porto Santo Stefano sits on the slopes of Monte Argentario, a promontory connected to the Tuscan coast by three slender spits of land. The port was subjected to frequent pirate raids until the Spanish fortified it in the 16th century, and the fortress still looms over the harbour.

Sardinia’s capital is a fascinating patchwork of historical architecture and vertiginous streets, crowned by the old hilltop citadel of Il Castello. Explore the island’s history at the Museo Archeologico, where you can learn about Sardinia's ancient Nuragic civilisation.

Tunisia’s capital is a whirlwind of energy, the narrow lanes of the old medina packed with people and the roads noisy with traffic. The more orderly streets of the Ville Nouvelle are home to some handsome colonial buildings, while the ruins of ancient Carthage make for a fascinating day trip.

Situated on the western edge of Sicily, closer to Tunis than it is to Rome, the historic port of Trapani has a discernible North African feel to it. This was once an important medieval trading centre that linked Carthage and Venice, and the lovely old town is a great place to spend some time exploring.

The picturesque little town of Amalfi was once a major Mediterranean naval power, but a devastating earthquake in 1343 cut the city down in its prime and destroyed most of its historic buildings. These days, of course, Amalfi is best known for the eponymous stretch of stunning coastline on which it sits.

The lovely town of Sorrento, draped across rugged cliffs overlooking the Bay of Naples, has been charming visitors since the days of the Grand Tour. The Renaissance palaces and many craft shops make Sorrento an attractive destination in its own right, and it’s also a jumping off point for Capri, Pompeii and the Amalfi Coast.