La Spezia is a busy port and Italy’s most important naval base, on the Ligurian coast to the south east of Genoa. The town itself has a certain authentic charm and an atmospheric old town, though you’ll most likely just be passing through en route to the beautiful villages of the nearby Cinque Terre.

One of the world’s great cities, Rome continues to dazzle and delight visitors with a potent mix of architectural marvels, continent-defining history and buzzing nightlife. The Colosseum, the Vatican and the Forum are among the big ticket items, with the crowds to match, though in truth you will find history around almost every corner.

The lovely town of Sorrento, draped across rugged cliffs overlooking the Bay of Naples, has been charming visitors since the days of the Grand Tour. The Renaissance palaces and many craft shops make Sorrento an attractive destination in its own right, and it’s also a jumping off point for Capri, Pompeii and the Amalfi Coast.

The volcanic island of Santorini (known officially as Thira) is one of the most spectacularly beautiful in the Mediterranean. The pretty village of Oia, with its whitewashed houses and windmills tumbling down the hillside, is particularly photogenic.

Marmaris is one of Turkey’s biggest beach resorts, with the crowds to match. It’s easy to see why so many are drawn here, with a great location on a mountainous bay, but we’d recommend heading further along the coast in search of quieter beaches and picturesque fishing villages.

Antalya is the biggest and busiest city on the Turkish Riviera, though there’s more to this place than just roasting on a beach. The historic Kaleiçi district is full of lovingly restored Ottoman mansions, and top attractions include the superb collection of classical treasures at the Antalya Museum, with pieces from the nearby archaeological sites of Perge and Aspendos.

Bodrum is one of the trendiest destinations on Turkey’s Aegean coast, with plenty of private yachts bobbing alongside the traditional gulet boats in the harbour. Whitewashed buildings draped in bougainvillea give the town a Greek feel, overlooked by the imposing 15th century crusader castle.

Saint John is said to have written the Book of Revelations in a cave on Patmos, and today the spot is marked by the hillside Monastery of the Apocalypse. As well as spirituality, the island is known for its beaches and upmarket vibe, with a scattering of stylish restaurants and bars.

Athens is a city awash with historical and cultural significance, but it's much more than an open air museum; this is a dynamic, bustling metropolis, and a place where history is still very much unfolding.

Glamorous Mykonos is the most popular of the Cyclades islands, well known as a haunt of the rich and the famous. It’s also the gateway to the nearby island of Delos, home to one of the most important archaeological sites in Greece.

Istanbul is the place where East meets West, where Asia Minor reaches out across the Bosphorus and almost touches Europe, and the city remains a bristling, bustling cultural melting pot, the skyline dotted with magnificent minarets and domes.

The Turkish port of Kusadasi is the gateway to Ephesus, one of the most spectacular archaeological sites in the Eastern Mediterranean. This was the Roman capital of Asia Minor, and the remains constitute the most complete classical city in Europe.

Sun-kissed Rhodes, the largest of the Dodecanese islands, is steeped in history; the medieval heart of Rhodes Town was once home to the crusading Knights of St John, and later fell to the Ottoman sultan Suleiman the Magnificent. The hillside village of Lindos, with its pretty whitewashed houses, is another highlight.

Malta’s tiny capital, established by the Knights of St John, packs in an awful lot of history considering its diminutive size. The atmospheric old streets, bathed in Mediterranean sunshine, are full of attractive honey-golden buildings, along with an impressive selection of bars and restaurants.

Palermo is an acquired taste; noisy, chaotic and rather grimey in places. But there’s something quite intoxicating about the crumbling facades and the bustling markets, and the Arabesque style of many of the buildings hints at Sicily’s historical role as a stepping stone between Europe and North Africa.

The picturesque little town of Amalfi was once a major Mediterranean naval power, but a devastating earthquake in 1343 cut the city down in its prime and destroyed most of its historic buildings. These days, of course, Amalfi is best known for the eponymous stretch of stunning coastline on which it sits.