Renowned for its food, its misty mornings and its vertiginous streets, cosmopolitan San Francisco is quite unlike any other American city. Highlights include the iconic Golden Gate Bridge, the delightful waterfront and the bohemian quarter of Haight Ashbury.

Astoria is the oldest city west of the Rockies, situated on the picturesque Oregon coast where the Columbia river meets the Pacific Ocean. This bustling port town is sometimes known as ‘Little San Francisco’, with handsome Victorian architecture, a proud fishing heritage and a buzzing, creative vibe.

Victoria is the capital of British Columbia and Canada’s westernmost city, with a distinctly English feel that occasionally borders on the twee. It’s a very walkable city, with handsome 19th century architecture, verdant parks and a lively harbour, and, this being Canada, the great outdoors is never far away.

Cosmopolitan Vancouver is a city that rewards exploration, an eminently liveable place and an easy gateway to the natural beauty of British Columbia. The culinary scene here is a particular draw, with seafood galore and some fantastic Asian restaurants.

Ketchikan is a great introduction to Alaska’s natural attractions, situated at the foot of towering Deer Mountain and within easy reach of the Misty Fjords. The colourful wooden buildings of Creek Street, the old red light district, are a reminder of Ketchikan’s former status as a rough and ready frontier town; these days, things are rather more civilised!

Sitka was founded by Russian fur traders in 1799 as the city of New Archangel, and there is still a discernible Russian influence here, including the distinctive St Michael’s Orthodox Cathedral. The town also enjoys spectacular natural surroundings, facing the Pacific Ocean and dramatic Mount Edgecumbe.

The tiny city of Seward, home to just 3,000 people, enjoys a spectacular setting on the edge of Resurrection Bay, on Alaska’s southern coast. Surrounded by the mountains and forests of the Kenai Fjords National Park, it’s a great base for exploring the Harding Ice Field and the stunning scenery of the Kenai Peninsula.

Kodiak is known as Alaska’s ‘Emerald Isle’ thanks to the lush green countryside, a landscape crisscrossed by gushing salmon-filled streams that provides a home to around 3,000 Kodiak bears, the world’s largest. Ships dock in Kodiak city, an important fishing port with a fascinating Russian heritage.

Dutch Harbor is the port that serves the city of Unalaska, and is known for the hardy fishermen who brave the turbulent, icy seas off the Aleutian Islands. Points of interest include the remains of defensive fortifications built during the Second World War and the striking Russian Orthodox church.

The misty fishing port of Kushiro, on the east coast of Hokkaido, is the gateway to the protected marshlands of Kushiro Mitsugen National Park. These extensive wetlands are the only place in Japan where you can still find the endangered Japanese crane, a graceful bird with a distinctive red crown.

Situated at the southern tip of Hokkaido, Hakodate was one of the first Japanese ports to open up to international trade in the 19th century, and a scattering of European-style buildings remain. Take a ride on the historic streetcar, tuck into delicious seafood or enjoy a revitalising dip in an onsen (hot spring).

In a state of constant renewal and forever looking to the future, densely populated Tokyo is a dazzling introduction to Japan and its utterly unique culture. With more neon than Las Vegas and more Michelin stars than Paris, it’s a real assault on the senses.

Shimizu is one of the most spectacular ports in Japan, a sweeping bay in the shadow of the iconic Mount Fuji. You can spend some time admiring the views and wandering through peaceful pine groves, or visit the unique Shimizu Sushi Museum at the S-Pulse Dream Plaza shopping mall.

Small in size and cosmopolitan in its outlook, Kobe is a thoroughly pleasant city with a long and distinguished history as one of Japan’s main trading ports. Kobe’s past as a commercial hub is reflected in its architecture, with a number of unusually European-looking houses, as well as a charming, if slightly touristy, Chinatown.

On 6 August 1945 the world witnessed the terrifying power of nuclear weapons for the first time, unleashed on the unsuspecting Japanese city of Hiroshima. The modern city's sobering Peace Memorial Park commemorates that fateful day, which left more than 140,000 dead.

The city of Miyazaki sits on the southeastern coast of Kyushu, the warmest of Japan’s main islands, and it’s a popular spot for domestic tourists. Worthwhile excursions include the historic town of Obi, known as ‘Little Kyoto’, and laid back Aoshima island, home to a picturesque shrine.

Ishigaki is the most developed of the Yaeyama islands, an idyllic tropical archipelago located closer to Taiwan than mainland Japan. The offshore coral reefs make this a popular spot for diving and snorkelling, while the jungle interior offers some great hiking opportunities.

Keelung is a fairly unremarkable port city close to Taipei, Taiwan’s capital. Taipei draws on an interesting mix of Chinese, Japanese and Western influences, and is home to attractive temples, a burgeoning street food scene and Taipei 101, which was the world's tallest building until it was eclipsed by Dubai's Burj Khalifa in 2010.

Hong Kong is a striking mix of ancient and modern, Chinese and British, and there is a lot more to the city than just skyscrapers and high finance. It's also a fantastic destination for foodies, a melting pot of culinary influences from around Asia and beyond.

Nha Trang is Vietnam’s premier beach destination, on a stunning bay dotted with idyllic islands. The main attraction is the laid back seaside atmosphere, but there are also a few noteworthy cultural sites, including the ancient Po Nagar Cham Towers, which were built between the 7th and 12th centuries.

Saigon, as it was known then, was the capital of the South during the Vietnam War, and American-style capitalism has been embraced more enthusiastically here than in the North, with a clutch of shining skyscrapers standing as testament to Vietnam’s surging economic growth.