Laid-back, friendly and blessed with near-perfect weather all year round, San Diego is one of America’s most likeable cities. Enjoy a stroll through Balboa Park, dotted with beautiful Spanish Renaissance-style architecture, take a whale watching trip along the coast, or sample the nightlife of the trendy Gaslamp Quarter.

The sister towns of Cabo San Lucas and San José del Cabo sit at the tip of Mexico’s Baja California peninsula. The towns themselves are mostly given over to luxury hotels and boisterous nightlife, but the surrounding landscape is characterised by arid arroyos, bristly cacti and rocky coastal outcrops.

Mazatlán is one of the most popular beach resorts on the Pacific coast of Mexico, and tourists tend to congregate in the Zona Dorada, where the majority of the hotels are concentrated. The old town is much more interesting, however, with elegantly faded colonial architecture and a vibrant cultural scene.

The resort town of Puerto Vallarta, on Mexico’s Pacific coast, has bags of charm in spite of its popularity. Spend some time exploring the pretty old town, with its cobbled streets and quirky boutiques, or relax on the beach. Humpback whales breed out in the bay during the winter months, and dolphins can be spotted year round.

Puerto Quetzal is the jumping off point for exploring the fascinating interior of Guatemala, and the highlight of this intriguing country has to be UNESCO-listed Antigua. This colourful colonial town, 90 minutes from the port, enjoys a spectacular setting against a backdrop of volcanoes, and is well worth the trip.

Situated on a peculiarly shaped peninsula on the Gulf of Nicoya, Puntarenas is a popular weekend beach destination for residents of Costa Rica’s capital, San José. The port itself is not pretty, but the beachfront Paseo de los Turistas is a nice place to relax with a drink or enjoy a seafood lunch.

The port of Fuerte Amador sits at the southern edge of Panama City, near the Pacific entrance to the Panama Canal. The shining skyscrapers of the Panamanian capital are a testament to the city’s status as a key financial centre, while the tiny Casco Viejo is home to pretty colonial streets, hip hotels and happening bars.

Situated just off the coast of Panama, the idyllic San Blas islands are home to the Kuna Indians, who enjoy political autonomy from the mainland and have an unusual degree of control over tourism to their homeland. Visiting these simple island communities is a privilege, and an insight into an indigenous way of life unsullied by mass tourism.

Cartagena was founded by Spanish conquistadors in 1533, and the beautifully preserved centre is a real highlight of Colombia’s Caribbean coast. The walled old town, the Ciudad Amurallada, is a camera-friendly collection of cobbled streets and colourful, colonial-era buildings.

Situated on Colombia’s Caribbean coast, Santa Marta is the oldest surviving Spanish colonial city in South America. The modern city lacks some of the charm of nearby Cartagena, but tourism has come on leaps and bounds in recent years, with a number of ambitious regeneration projects and a host of new restaurants and bars.

Downtown Miami is a destination in its own right, with a host of world class galleries, but it's still Miami Beach that draws the biggest crowds. The Art Deco district around South Beach is very much back in vogue, with new restaurants, bars and luxury developments sprouting up all over the place.

Gustavia is the chic and petite capital of Saint Barths, a tiny French Caribbean island that’s renowned as a haunt of the rich and the famous. You can certainly live well here if you’ve got the means, with an array of gourmet restaurants and luxury boutiques aimed squarely at the A-list. The beautiful beaches, on the other hand, are free and open to all.

Antigua is famously home to 365 beaches - one for every day of the year - and there is an undeniable allure to the many white sand coves dotted along the coast. The capital, St John's, is worth a look, but if you've got time to visit the south coast you'll find historic Nelson's Dockyard a lot more interesting.

The lush volcanic island of La Palma is one of the Canary Islands’ best kept secrets, a place where tourism is still low key and the beautiful scenery is unspoilt by high rise developments. Don’t miss the colourful colonial architecture of the capital, Santa Cruz, reminiscent of the Spanish Caribbean.

In recent years Lanzarote has begun to shake off its mass market reputation and reinvent itself as a more upmarket destination. The extraordinary volcanic landscapes and the works of local artist César Manrique give the island a unique appearance, and the understated capital, Arrecife, is well worth exploring.

Bustling and modern, fizzing with industry and commerce, Casablanca is often overlooked in favour of Morocco’s better known tourist draws. But then this is part of its appeal: it’s an authentic and unvarnished city, and it’s also home to the spectacular modernist architecture of the Hassan II Mosque.

After years of neglect, Tangier is finally being restored to its former glory as a cosmopolitan crossroads between Europe and Africa. The Moroccan government has invested heavily in modern infrastructure, while the spruced up medina shines with a new-found cultural dynamism.

Málaga boasts plenty of chic restaurants and bars where you can ease into the rhythms of life in southern Spain, before exploring sights including the intriguing, unfinished Gothic cathedral, and a museum devoted to the city's most famous son, Pablo Picasso.

Cartagena was founded by Spanish conquistadors in 1533, and the beautifully preserved centre is a real highlight of Colombia’s Caribbean coast. The walled old town, the Ciudad Amurallada, is a camera-friendly collection of cobbled streets and colourful, colonial-era buildings.

Spain’s third city is a dazzling destination that combines historic architecture, cutting edge design and an inviting stretch of beach. Don’t miss the futuristic City of Arts and Sciences, designed by local architect Santiago Calatrava, or the old riverbed, now a delightful park.