Glamorous Mykonos is the most popular of the Cyclades islands, well known as a haunt of the rich and the famous. It’s also the gateway to the nearby island of Delos, home to one of the most important archaeological sites in Greece.

Lesvos is the third largest of the Greek islands, with a landscape ranging from arid plains and rocky outcrops to lush olive groves, forested mountains and sandy beaches. Highlights include the beautiful harbour at Molyvos and the ruined Byzantine fortress that overlooks Mytilini, the island’s lively capital.

The Aegean island of Bozcaada, also known as Tenedos, is a popular weekend and summer escape for residents of Istanbul. The main settlement, Bozcaada Merkez, has an atmospheric Greek quarter full of colourful houses, while elsewhere on the island you'll find vineyards, beaches and an impressive castle.

Istanbul is the place where East meets West, where Asia Minor reaches out across the Bosphorus and almost touches Europe, and the city remains a bristling, bustling cultural melting pot, the skyline dotted with magnificent minarets and domes.

The Turkish port of Kusadasi is the gateway to Ephesus, one of the most spectacular archaeological sites in the Eastern Mediterranean. This was the Roman capital of Asia Minor, and the remains constitute the most complete classical city in Europe.

Marmaris is one of Turkey’s biggest beach resorts, with the crowds to match. It’s easy to see why so many are drawn here, with a great location on a mountainous bay, but we’d recommend heading further along the coast in search of quieter beaches and picturesque fishing villages.

Antalya is the biggest and busiest city on the Turkish Riviera, though there’s more to this place than just roasting on a beach. The historic Kaleiçi district is full of lovingly restored Ottoman mansions, and top attractions include the superb collection of classical treasures at the Antalya Museum, with pieces from the nearby archaeological sites of Perge and Aspendos.

The buzzing city of Limassol is southern Cyprus’ main port, an important commercial hub that overflows with bars, restaurants and tavernas. It’s also home to a pleasant old town and medieval castle, and serves as an excellent base for exploring the nearby Troodos mountains.

Sun-kissed Rhodes, the largest of the Dodecanese islands, is steeped in history; the medieval heart of Rhodes Town was once home to the crusading Knights of St John, and later fell to the Ottoman sultan Suleiman the Magnificent. The hillside village of Lindos, with its pretty whitewashed houses, is another highlight.

The volcanic island of Santorini (known officially as Thira) is one of the most spectacularly beautiful in the Mediterranean. The pretty village of Oia, with its whitewashed houses and windmills tumbling down the hillside, is particularly photogenic.

Crete’s bustling capital is a modern and cosmopolitan city, where the island’s rich history isn’t immediately apparent. Take a closer look, however, and you’ll find a fantastic archaeological museum, along with remnants of Venetian fortifications and a lively seafront promenade, with plenty of nice outdoor cafés.

Malta’s tiny capital, established by the Knights of St John, packs in an awful lot of history considering its diminutive size. The atmospheric old streets, bathed in Mediterranean sunshine, are full of attractive honey-golden buildings, along with an impressive selection of bars and restaurants.

Tunisia’s capital is a whirlwind of energy, the narrow lanes of the old medina packed with people and the roads noisy with traffic. The more orderly streets of the Ville Nouvelle are home to some handsome colonial buildings, while the ruins of ancient Carthage make for a fascinating day trip.

Palermo is an acquired taste; noisy, chaotic and rather grimey in places. But there’s something quite intoxicating about the crumbling facades and the bustling markets, and the Arabesque style of many of the buildings hints at Sicily’s historical role as a stepping stone between Europe and North Africa.

The UNESCO World Heritage-listed centre of Naples rewards exploration, and in addition to the many cultural treasures waiting to be unearthed Neapolitans are rightly proud of their food; this is where you’ll find the best pizza in Italy. The city also acts as a gateway to the fascinating remains of Pompeii and Herculaneum, and the beautiful Amalfi coast.

One of the world’s great cities, Rome continues to dazzle and delight visitors with a potent mix of architectural marvels, continent-defining history and buzzing nightlife. The Colosseum, the Vatican and the Forum are among the big ticket items, with the crowds to match, though in truth you will find history around almost every corner.

The faded port town of Livorno serves as a gateway to Tuscany’s star attractions. Wonderful Florence, the cradle of the Renaissance, is resplendent with beautiful architecture and unrivalled artistic treasures, while nearby Pisa is of course famous for its precarious Leaning Tower.

The Corsican port of Calvi is a popular summer destination for both sun-seeking tourists and the yachts of the super-rich, with a swanky harbour and five miles of beautiful beach. The town is said by some to be the birthplace of Christopher Columbus, and the skyline is dominated by the imposing 15th century Genoese citadel.

Few ports conjure up images of glitz and movie star glamour quite so readily as Cannes. May is when the glitterati roll into town for the Film Festival, but there’s still plenty to divert you the rest of the year, including the old quarter, Le Suquet, and the dazzling Croisette.

Toulon is not the sort of place you would expect to find on the Côte d’Azur, a gritty port city that’s home to France’s most important naval base. It’s not completely without charm, however, and for some travellers it may come as a breath of fresh air after the glitz of the Riviera. For the best view, take the cable car to the top of Le Faron mountain.

From the warren-like medieval streets of the Barri Gòtic to the fantastical modernist architecture of Antoni Gaudí, from the dizzy heights of Mount Tibidabo to the golden sands of Barceloneta, there’s never a dull moment in Barcelona.

Mallorca is renowned for its beaches, ranging from big, bustling resorts to small, secluded coves. The island interior offers ruggedly beautiful scenery and quaint little towns, while the charming capital, Palma, boasts an attractive old quarter dominated by the imposing Gothic cathedral.

Cartagena was founded by the Carthaginians around 227 BC, who named it after their home city in North Africa. These days the city is best known for its well-preserved Roman theatre, which was remarkably only discovered in 1987, in spite of its location in the centre of town.