The North Aegean port of Dikili is the gateway to the spectacular hilltop ruins of Pergamum, a 30-minute drive away. Most of the buildings here date back to the 2nd century BC, including the main palace, the library and the Altar of Zeus, and the ruins were declared a UNESCO World Heritage Site in 2014.

The Turkish port of Kusadasi is the gateway to Ephesus, one of the most spectacular archaeological sites in the Eastern Mediterranean. This was the Roman capital of Asia Minor, and the remains constitute the most complete classical city in Europe.

Saint John is said to have written the Book of Revelations in a cave on Patmos, and today the spot is marked by the hillside Monastery of the Apocalypse. As well as spirituality, the island is known for its beaches and upmarket vibe, with a scattering of stylish restaurants and bars.

The volcanic island of Santorini (known officially as Thira) is one of the most spectacularly beautiful in the Mediterranean. The pretty village of Oia, with its whitewashed houses and windmills tumbling down the hillside, is particularly photogenic.

Sun-kissed Rhodes, the largest of the Dodecanese islands, is steeped in history; the medieval heart of Rhodes Town was once home to the crusading Knights of St John, and later fell to the Ottoman sultan Suleiman the Magnificent. The hillside village of Lindos, with its pretty whitewashed houses, is another highlight.

Alanya has a reputation as a brash resort town, but there are still remnants of its fascinating history. This was a key bastion of the Seljuk Turks as they spread west into Anatolia, and you can visit the fortress and walls that they built to defend the city. Other sights include the Kizil Kule, an octagonal 13th-century tower by the harbour.

The buzzing city of Limassol is southern Cyprus’ main port, an important commercial hub that overflows with bars, restaurants and tavernas. It’s also home to a pleasant old town and medieval castle, and serves as an excellent base for exploring the nearby Troodos mountains.

It's difficult to overstate the spiritual significance of Jerusalem, a holy city to three different faiths: Christianity, Islam and Judaism. Whatever your personal beliefs, it's impossible not to be moved by sights such as the Wailing Wall, the Dome of the Rock and the Church of the Holy Sepulchre.