Saint John is said to have written the Book of Revelations in a cave on Patmos, and today the spot is marked by the hillside Monastery of the Apocalypse. As well as spirituality, the island is known for its beaches and upmarket vibe, with a scattering of stylish restaurants and bars.

The Turkish port of Kusadasi is the gateway to Ephesus, one of the most spectacular archaeological sites in the Eastern Mediterranean. This was the Roman capital of Asia Minor, and the remains constitute the most complete classical city in Europe.

It's difficult to overstate the spiritual significance of Jerusalem, a holy city to three different faiths: Christianity, Islam and Judaism. Whatever your personal beliefs, it's impossible not to be moved by sights such as the Wailing Wall, the Dome of the Rock and the Church of the Holy Sepulchre.

Haifa is Israel’s third city, a bustling and multicultural place where six different faiths live side by side. The city is the spiritual centre of the Baha’i Faith, and the beautiful Baha’i Gardens are a must-see. Many cruise visitors opt to skip Haifa and take an excursion to Jerusalem and Bethlehem, two to three hours’ drive away.

Named European Capital of Culture in 2017, Paphos actually consists of two towns. Ktima, the Upper Town, is home to elegant colonial architecture and several museums, while Kato Pafos, the Lower Town, is more geared towards tourism, with bars, souvenir shops and the impressive Archaeological Park.

Sun-kissed Rhodes, the largest of the Dodecanese islands, is steeped in history; the medieval heart of Rhodes Town was once home to the crusading Knights of St John, and later fell to the Ottoman sultan Suleiman the Magnificent. The hillside village of Lindos, with its pretty whitewashed houses, is another highlight.

The charming port of Agios Nikolaos, on the north east coast of Crete, offers a beguiling blend of characterful tavernas, lively bars and designer boutiques. The town is centred around little Lake Voulismeni, and nearby attractions include some lovely beaches and the Minoan ruins at Gournia.

The volcanic island of Santorini (known officially as Thira) is one of the most spectacularly beautiful in the Mediterranean. The pretty village of Oia, with its whitewashed houses and windmills tumbling down the hillside, is particularly photogenic.

Glamorous Mykonos is the most popular of the Cyclades islands, well known as a haunt of the rich and the famous. It’s also the gateway to the nearby island of Delos, home to one of the most important archaeological sites in Greece.