It's difficult to overstate the spiritual significance of Jerusalem, a holy city to three different faiths: Christianity, Islam and Judaism. Whatever your personal beliefs, it's impossible not to be moved by sights such as the Wailing Wall, the Dome of the Rock and the Church of the Holy Sepulchre.

The buzzing city of Limassol is southern Cyprus’ main port, an important commercial hub that overflows with bars, restaurants and tavernas. It’s also home to a pleasant old town and medieval castle, and serves as an excellent base for exploring the nearby Troodos mountains.

Sun-kissed Rhodes, the largest of the Dodecanese islands, is steeped in history; the medieval heart of Rhodes Town was once home to the crusading Knights of St John, and later fell to the Ottoman sultan Suleiman the Magnificent. The hillside village of Lindos, with its pretty whitewashed houses, is another highlight.

The Turkish port of Kusadasi is the gateway to Ephesus, one of the most spectacular archaeological sites in the Eastern Mediterranean. This was the Roman capital of Asia Minor, and the remains constitute the most complete classical city in Europe.

The Aegean island of Bozcaada, also known as Tenedos, is a popular weekend and summer escape for residents of Istanbul. The main settlement, Bozcaada Merkez, has an atmospheric Greek quarter full of colourful houses, while elsewhere on the island you'll find vineyards, beaches and an impressive castle.

Istanbul is the place where East meets West, where Asia Minor reaches out across the Bosphorus and almost touches Europe, and the city remains a bristling, bustling cultural melting pot, the skyline dotted with magnificent minarets and domes.

Kavala has a rich history dating back nearly 3,000 years, and was known in antiquity as Neapolis. Many of the city’s most interesting sights were built by the Ottomans, including the aqueduct of Suleyman the Magnificent and the beautiful Imaret, a former religious school.

Glamorous Mykonos is the most popular of the Cyclades islands, well known as a haunt of the rich and the famous. It’s also the gateway to the nearby island of Delos, home to one of the most important archaeological sites in Greece.

The volcanic island of Santorini (known officially as Thira) is one of the most spectacularly beautiful in the Mediterranean. The pretty village of Oia, with its whitewashed houses and windmills tumbling down the hillside, is particularly photogenic.

Taormina enjoys a truly spectacular setting on Sicily’s east coast, perched on a mountainside looking out towards the smouldering Mount Etna. The medieval streets are pleasant but often crowded in high season, so we’d recommend getting out and exploring the surrounding countryside.

The lovely town of Sorrento, draped across rugged cliffs overlooking the Bay of Naples, has been charming visitors since the days of the Grand Tour. The Renaissance palaces and many craft shops make Sorrento an attractive destination in its own right, and it’s also a jumping off point for Capri, Pompeii and the Amalfi Coast.

One of the world’s great cities, Rome continues to dazzle and delight visitors with a potent mix of architectural marvels, continent-defining history and buzzing nightlife. The Colosseum, the Vatican and the Forum are among the big ticket items, with the crowds to match, though in truth you will find history around almost every corner.

Situated on the northeastern coast of Sardinia, Olbia is a busy port city that serves mostly as a gateway to the beautiful Costa Smeralda. The compact historic centre has some pleasant places to eat, drink and shop if you feel like exploring, or you may prefer to head straight for the beach.

The faded port town of Livorno serves as a gateway to Tuscany’s star attractions. Wonderful Florence, the cradle of the Renaissance, is resplendent with beautiful architecture and unrivalled artistic treasures, while nearby Pisa is of course famous for its precarious Leaning Tower.

Renowned for its casino, its Grand Prix and its oligarch-friendly tax policies, Monte Carlo is glamour and hedonism personified, with a price tag to match. This little principality enjoys a lovely setting, the villas and penthouses tumbling down the hillside towards the sweeping blue expanse of the Mediterranean.

Ever since Brigitte Bardot put Saint Tropez on the map with the seminal ‘And God Created Woman’ in 1956, this diminutive fishing village on the French Riviera has been a magnet for the international glitterati.

Originally founded by the Greeks in the 4th century BC, and later an important Roman town, the pretty port of Antibes has a rich history. The charming old town, surrounded by Vauban’s medieval ramparts, has inspired many artists and writers over the years, including Picasso, Monet and Graham Greene.

The bustling fishing village of Palamós is one of the loveliest spots on the Costa Brava, surrounded by beautiful beaches and rugged coves. You can also use your stop here as a jumping off point for exploring nearby medieval villages, the historic city of Girona or the fantastic Salvador Dalí museum in Figueres.

Mallorca is renowned for its beaches, ranging from big, bustling resorts to small, secluded coves. The island interior offers ruggedly beautiful scenery and quaint little towns, while the charming capital, Palma, boasts an attractive old quarter dominated by the imposing Gothic cathedral.